Creon 25000 supply update

Update 2 April 2024

There are currently short-term issues with supply of Creon (particulary 25,000) in some areas. The Trust is in contact with the NHS, Viatris (the company that makes Creon), and CF clinicians, to minimise the impact of any shortages.

The British Dietetic Association (BDA) CF Specialist Group has prepared guidance for adults with CF, clinical teams, and primary care practitioners such as GPs to assist with managing supply and minimising the impact on CF symptoms whilst issues are ongoing.

We have summarised the general guidance for people with CF below.  It is important to note that pancreatic enzymes are still being delivered regularly into the United Kingdom, so supply issues are usually temporary. It is not expected that individuals with CF will experience extended or ongoing shortages. 

If you are unable to access Creon or are experiencing abdominal symptoms due to issues with your usual supply, please speak to your CF dietitian or another member of your CF team. They will be able to provide you with tailored advice to minimise any impact on your health. 

General guidance for adults with CF: 

The BDA CF Group, together with the CF Medical Association, has issued the following guidance. It is recommended that people with CF try these steps to maximise Creon availability whilst supply issues are ongoing:

  • Please do not stockpile medicines, as this will further impact supply.
  • The Department of Health and Social Care has recommended that only 1-month supply is issued at a time to try and regulate supplies, so if you currently receive 2–3 months of Creon at a time, you will need to collect your prescriptions more frequently. (If you pay for your prescription, consider buying a prescription prepayment certificate to reduce the cost of prescription charges. 
  • Place your prescription requests 2 weeks earlier than usual to give the community pharmacist time to source your medication. 
  • You may need a change in your repeat prescriptions if what you usually have is not available. There are three brands of pancreatic enzyme replacement therapy (PERT) available currently in the UK (Creon, Nutri-zym, and Pancrex). Your dietitian will advise you on what dosing to use if you do need to switch to a different brand.  
  • Remember to store your PERT appropriately. All PERT should be stored below 25 degrees, and some brands recommend refrigeration. If PERT gets too hot it does not work properly, and this damage cannot be reversed. 
  • Taking PERT throughout the meal rather than all at the start, middle or end improves how well it digests the food and drinks you are eating or drinking. 
  • Ensure that you use your PERT before it goes out of date. If you store PERT in different places (such as at work), make sure you rotate your supplies to prevent any wastage.

If you are experiencing abdominal symptoms due to being unable to access your usual Creon supply, or if you are unable to access Creon at all, please speak to your CF team for detailed guidance.

Please also make your CF team aware if you’re having difficulties getting hold of the Creon you need. This will help the NHS and the manufacturers of Creon understand how widespread the supply issues are, and identify how best to address any shortages.

What advice is there for babies and children?

Most babies, toddlers and young children use powder/granules/standard strength capsules, which are not currently affected by supply issues. Young people who experiencing supply issues of the higher strength enzymes should contact their specialist CF team for advice.

Update 19 February 2024

We have been updated that Creon (particularly 25,000) is experiencing further short-term issues with supply. The Department of Health and Social Care are in regular communication with suppliers and clinicians to understand what actions can be taken to minimise the impact of this shortage.

Please speak to your CF team if you’re having difficulties getting hold of the Creon you need.

Update on 5 February 2024

The UK Governments have confirmed that they are working with the manufacturers of Creon to help ensure that action is taken to resolve any further issues that may arise.

You can read the written questions and answers here:

Please speak to your CF team if you’re having difficulties getting hold of the Creon you need.

Update on 26 January 2024

We've been updated that Creon 25000 should now be in stock, but there may be some short-term issues with supply of Creon 10000. We understand that more deliveries are expected over the next few weeks. Please speak to your CF team if you have trouble getting hold of Creon in the strength you need. 

Update on 22 December 2023

We've been in touch with Viatris, who produce Creon, to check for any current supply issues. They have confirmed that there is stock of Creon in the UK in all strengths and stock is arriving regularly. If you are struggling to get either Creon 25k or Creon 10k from your local pharmacy, please contact your CF team.

22 November 2023

Over recent months, we’ve heard a number of reports from people with cystic fibrosis that their local pharmacies have been unable to supply Creon 25000. Together with specialist CF pharmacists, we’ve been monitoring this, and we have been speaking to Viatris, the manufacturer of Creon, to highlight this issue.

We’ve been told that there have been supply issues with Creon 25000, but that Creon 10000 has been available. While this does give some reassurance that this essential medication remains available, for many people with CF it does mean taking extra pills with every meal, on top of an already high number of pills and medications every day.

Last week, Viatris told us that they now have Creon 25000 in stock across the UK, and this is being distributed via their supply chains, and the supply issue will be resolved in the coming days. This is positive, and we hope this means people with CF will be able to access Creon 25000 again via their local pharmacies.

We will continue to monitor this. If you are unable to get Creon 25000, please do speak to your CF team for advice first, and we’d also be grateful if you can let us know so we can report any further issues straight to the manufacturer. It would also be useful for us to know where in the UK you are. You can contact us to tell us if you’re not able to get Creon 25000 by emailing [email protected].

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