Covid-19 Antibody Responses in Cystic Fibrosis (CAR-CF)

Details

CTAP badge
Therapeutic approach
Other
Trial status
Open to recruitment Participating Centres
Trials Tracker ID
TT007531
Last updated
25/05/2022

Full title

Covid-19 Antibody Responses in Cystic Fibrosis (CAR-CF)

Study details

Coronavirus disease 2019 (COVID-19) which is caused by the virus SARS-CoV-2 has resulted in an ongoing global pandemic. It is unclear whether the relatively low number of reported cases of COVID-19 in people with CF (pwCF) is due to enhanced infection prevention practices or whether pwCF have protective genetic/immune factors.



This study aims to prospectively assess the proportion of pwCF, including both adults and children with CF who have evidence of SARS-CoV-2 antibodies over a two-year period. This study will also examine whether pwCF who have antibodies for SARS-CoV-2 have a different clinical presentation and what impact this has on their CF disease.



The proposed study will recruit pwCF from paediatric and adult CF centres throughout the UK and other countries in Europe, Canada and the US.


Phase
Not applicable
Length of participation
2 years
Recruitment target
1000
CF sponsor
ECFS-CTN

Who can take part?

Age range
Any age
Including people

Consenting people with cystic fibrosis of any age, genotype, transplant status and disease severity will be eligible to participate in the study

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CF centres running this trial

Recruiting

Belfast

CTAP centre
NHS Trust
Belfast Health & Social Care Trust
Local site investigator
Dr Damien Downey
Trial Coordinators
Catherine McNeill
Recruiting

Cardiff

CTAP centre
NHS Trust
Cardiff and Vale University Health Board
Local site investigator
Dr Jamie Duckers and Dr Lena Thia
Trial Coordinators
Catherine Joyce
Recruiting

King's College Hospital (London)

CTAP centre
NHS Trust
King's College Hospital NHS Foundation Trust
Address
King's College Hospital
Denmark Hill
SE5 9RS
Local site investigator
Dr Michael Waller
Trial Coordinators
Mélanie Le Sayec
Recruiting

Leeds

CTAP centre
NHS Trust
The Leeds Teaching Hospitals NHS Trust
Address
St James's University Hospital
Beckett Street
LS9 7TF
Local site investigator
Dr Daniel Peckham
Trial Coordinators
Yasmin Khanagha
Helen Chadwick
Recruiting

Royal Brompton Hospital (London)

CTAP centre
NHS Trust
Guy's and St Thomas' NHS Foundation Trust
Address
Royal Brompton Hospital
Sydney Street
SW3 6NP
Local site investigator
Dr Nicholas Simmonds
Trial Coordinators
Sophie Pinnell
Recruiting

Southampton General Hospital

CTAP centre
NHS Trust
University Hospital Southampton NHS Foundation Trust
Address
Tremona Road
SO16 6YD
Local site investigator
Dr Mary Carroll
Trial Coordinators
Matthew Harvey
Closed

Birmingham Heartlands Hospital (Adults)

CTAP centre
NHS Trust
University Hospitals Birmingham NHS Foundation Trust
Address
Bordesley Green
B9 5SS
Local site investigator
Dr Joanna Whitehouse and Dr Maya Desai
Trial Coordinators
Aoife Neal
Closed

Glasgow

CTAP centre
NHS Trust
NHS Greater Glasgow & Clyde
Local site investigator
Dr Gordon MacGregor
Trial Coordinators
Annie Husband
Closed

Nottingham

CTAP centre
NHS Trust
Nottingham University Hospitals NHS Foundation Trust
Local site investigator
Dr Helen Barr
Trial Coordinators
Fozia Naushahi
Gillian Black