A study of web and tablet-based interactive audiometry in adult CF.

Details

Therapeutic category
Other
Trial status
Completed Participating Centres
Phase
Not Applicable

Full title

A prospective cross-sectional study analysing the utility of novel tablet-based audiometry and an interactive web-based hearing app as screening tools for drug-induced ototoxicity in adults with cystic fibrosis.

Adults with CF regularly receive anti-infective therapy that can result in impaired hearing. Recent studies have identified that up to 50% of adults with CF have hearing loss with resulting significant impact on quality of life. At present, however, there is no national recommendation to screen for hearing loss within adult CF.
Formal hearing tests are costly, require specialist staff and equipment and require further outpatient visits resulting in significant impact on health, social and financial resource. A novel interactive Apple-iPad app-based audiometer is now available and CE marked (Shoebox MD, Clearwater Medical) that can be used by non-audiologists to test hearing in a standard outpatient setting. Furthermore a novel interactive web-based hearing app has recently been developed (3D Tune-In). This technology has not been used to date in an adult cohort such as people with cystic fibrosis.
We propose to analyse over a 12 month period at two adult cystic fibrosis centres in London whether outpatient tablet based audiometry testing and web-based hearing apps are able to accurately screen for ototoxicity in adults with CF, and whether these methods of screening are acceptable. We will determine whether this technology is as reliable as formal hearing tests and better than standard questionnaire-based screening. We will examine whether this approach can be used within the existing CF outpatient clinic by non-specialist staff to enable streamlining of care. Through this project we will also determine the incidence and significance of certain genetic mutations in predisposition to hearing loss in CF to inform further studies.
The results of this study will aim to streamline audiometry screening to improve detection rates, reduce cost of healthcare, enable equity in service delivery, and minimize disruption to the patient’s social and work-life using smart technology. The study is being sponsored by the NHS Darzi fellowship scheme and UK CF trust.
Trial Reference Number
99211
Trial type
Non-medication
Length of participation
Two visits which include three hearing tests, a blood test and questionnaires.
Intervention
Audiometry
Recruitment target
200
Last edited date
22/03/2019
CF sponsor
Royal Brompton and Harefield NHS Foundation Trust
CF sponsor type
Academic

Who can take part?

Age
16+
Top inclusion criteria
  • 16 years old and above.
  • Treated at Royal Brompton Hospital or Kings College Hospital
Top exclusion criteria
  • Patients with previously diagnosed visual impairment
  • Inability to attend audiology outpatient appointments due to state of health
  • Established hearing loss with hearing aids in use

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