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Day one is designed for a multi-disciplinary clinical, research and academic audience - providing the latest pipeline of international cystic fibrosis (CF) research and innovation.
9.00 Registration and networking (Hall 5 foyer)
10.00 Welcome and conference introduction (Hall 5)
David Ramsden, Chief Executive, Cystic Fibrosis Trust
10.10 Setting the scene for day one
Dr Janet Allen, Director of Strategic Innovation, Cystic Fibrosis Trust
10.15-11.10 - Session one: Latest developments in the therapeutic pipeline for CF.
Chair: Oli Rayner, Special Advisor, Research and Patient Involvement, Cystic Fibrosis Trust
10.20 Potential disease-modifying new treatments in the pipeline
Dr Damian Downey, Clinical Senior Lecturer, Queens University Belfast
- Latest information on various transformational treatments in development
- Explanation on triple terminology
- Likely timeframe
10.45 Survival, treatments and transplant: Using the Registry today to inform CF care tomorrow
Dr Ruth Keogh, Associate Professor of Medical Statistics, London School of Hygiene and Tropical Medicine
- Personalised information on survival and forecasting future population trends
- Understanding the long-term impact of Ivacaftor
- Learning about the transplant pathway in the UK
11.10 Coffee and networking (Exhibition area - Hall 8)
11.25-12.20 - Session two: Putting the person into personalised medicine.
Chair: Dr Mandy Bryon, Consultant Clinical Psychologist, Great Ormond Street Hospital
11.30 Delivery of care for people with CF: Co-designing the future!
Professor Stuart Elborn, Professor of Respiratory Medicine, Imperial College London & Royal Brompton Hospital
- The current model of care is unsustainable
- External pressures: the rising number of adults with CF
- Changing expectations of parents and people with CF
- Novel solutions
11.55 How do we ensure the person is at the centre of their care?
Professor Rob Horne, Professor of Behavioural Medicine, Director, Centre for Behavioural Medicine, UCL School of Pharmacy, University College London
- Is personalised medicine achievable?
- Impact on the individual and clinical teams
- Impact on clinical trials
12.20 Conference lunch (Exhibition Area - Hall 8)
'Meet the sponsors’, networking & poster viewing (Exhibition Area – Hall 8)
13.00-13.50 Vertex symposium (Hall 5)
14.00-14.55 - Session three: Pulmonary complications of CF.
Chair: Professor Michael Tunney, Professor of Clinical Pharmacy, Queens University, Belfast
14.05 CF MATTERS - Comparing the use of microbiome-directed antibiotic treatment versus standard therapy for patients with CF experiencing respiratory infections.
Professor Barry Plant, Consultant Respiratory Physician and Director, Adult CF centre, Cork University Hospital; Clinical Senior Lecturer at University College
- Large EU-funded collaboration across Europe to understand pulmonary infection for CF
- Microbiome analysis
- Insights into pulmonary infections following long term ivacaftor therapy
14.30 Protection against emerging pathogens
Dr Charles Haworth, Director, Cambridge Centre for Lung Infection
- Challenges of Mycobacterium abscessus
- Novel hospital design
14.55-15.50 - Session four: Regenerative medicine.
Chair: Professor Steve Hart, Professor in Molecular Genetics, UCL Institute of Child Health
15.00 CF-related diabetes. Is it possible for the pancreatic islets to regenerate?
Professor James Shaw, Professor of Regenerative Medicine for Diabetes and Honorary Consultant Physician, Newcastle University
- Significance of CF-related diabetes
- Is loss of pancreatic islets secondary to pancreatic damage?
- Can islets regenerate?
15.25 Gene editing – how do we get from cells in a lab to lungs in a person?
Patrick Harrison, Senior Lecturer, Department of Physiology, University College Cork, Ireland
- Long-term goal to find the pathway to a CF ‘cure’ harnessing gene editing to deliver over the next 10 years
- Small molecule treatments
- All possible in the lab. What are the bottle necks to therapies
15.50 Closing comments and close of conference day one
16.45 'CF's Got Talent!' (Hall 5)
- Presentations & award ceremony
- For early career CF researchers & people with CF and their families
- Full online streaming and interaction with CF community
Summer Students Poster Session – judging panel (Exhibition area - Hall 8)
19.00 Drinks reception and networking opportunity
19.30 Conference and fundraising gala dinner (Hall 9)
Guest speaker: TBC
Prizes awarded for CF's Got Talent! and Summer Students
22.00 Close of day one
This meeting is supported by companies, including pharmaceutical companies, who will be exhibiting at the event and pharmaceutical staff will be present throughout the meeting.