CF START
Details
- Therapeutic category The type of treatment or therapy being studied. A therapy could range from a medication addressing a particular characteristic of CF to a device or activity e.g. exercise
- Anti-Infective
- Trial status
- Open to recruitment Participating Centres
- Phase The different stages involved in the development of a new medication. Phase I focuses on initial safety in people. Phase 2 evaluates safety, correct dose and early signs of whether the medication works. Phase 3 is the stage before medication licensing and looks at safety and medication effectiveness. Phase 4 evaluates longer term use of a medication after it has been licensed for use
- Phase IV
Full title
The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial (CF START); a randomised registry trial to assess the safety and efficacy of flucloxacillin as a longterm prophylaxis agent for infants with CF.
CF START is a national UK trial that will determine the safest and most effective antibiotic strategy for infants diagnosed with cystic fibrosis (CF). 480 CF infants will be randomly allocated either flucloxacillin prophylaxis (the current UK standard of care) or antibiotics given in a more targeted manner. The primary outcome will be the age at first growth of Pseudomonas aeruginosa from a respiratory culture (an important safety measure for families). All outcomes will be recorded on a national CF Registry, including a number of secondary outcomes assessing effectiveness and safety. Finally at 40-48 months, a measure of respiratory function will be undertaken in a central laboratory, which will provide a clearer indication of the effectiveness of these two strategies.- Trial Reference Number
- 86464
- Trial type
- Medication
- Length of participation The length of time a participant will take part in a trial, from the first to the last appointment
- 48 months
- Intervention The name of the treatment or therapy being researched
- Flucloxacillin antiobiotic
- Recruitment target The number of participants who need to be recruited for the trial in the UK
- 480
- Last edited date
- 30/09/2020
- CF sponsor
- Alder Hey Children's NHS Foundation Trust
- CF sponsor type
- Academic
Who can take part?
- Age
- 70 days or less
- Top inclusion criteria
- Two CF-causing mutations are identified OR one or no CF- causing mutations identified, sweat chloride test result > 59 mmol/L
- Age 70 days or less
- Consent for inclusion on the national UK CF Registry
- Consent for inclusion in the CF START trial
- Top exclusion criteria
- An inconclusive diagnosis after newborn screening (NBS)
- Previous growth of Pseudomonas aeruginosa from respiratory culture
CF centres running this trial
Recruiting
Addenbrooke's Hospital (CUH)
- Address
-
Addenbrookes Hospital
Hill Road
Cambridge
Cambridgeshire CB2 0QQ - Recruitment starts
-
- Contact
-
McShane, Donna
Recruiting
Alder Hey Children's Hospital
- Address
-
Alder Hey Hospital
Eaton Road
West Derby
Liverpool
Merseyside L12 2AP - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Southern, Kevin
Recruiting
BRADFORD ROYAL INFIRMARY
- Address
-
BRADFORD ROYAL INFIRMARY, DUCKWORTH LANE, BRADFORD, WEST YORKSHIRE,
BD9 6RJ - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Shenoy, Anil
Recruiting
Birmingham Children's Hospital
- Address
-
Steelhouse Lane
Birmingham
West Midlands B4 6NH - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Desai, Maya
Recruiting
Blackpool Victoria Hospital
- Address
-
Blackpool Victoria Hospital
Whiney Heys Road
Blackpool FY3 8NR - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Rowlands, Alan
Recruiting
Brighton and Sussex University Hospitals NHS Trust
- Address
-
Sussex Cancer Centre
Royal Sussex County Hospital
Eastern Road
Brighton BN2 5BE - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Seddon, Paul
Recruiting
Burnley General Teaching Hospital
- Address
-
Burnley General Teaching Hospital
Casterton Avenue
Burnley
Lancashire BB10 2PQ - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Robertson, Tanya
Recruiting
CALDERDALE ROYAL HOSPITAL
- Address
-
CALDERDALE ROYAL HOSPITAL, SALTERHEBBLE, HALIFAX, WEST YORKSHIRE,
HX3 0PW - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Mattara, Abdul
Recruiting
Cardiff & Vale UHB R&D Office - Secondary Care
- Address
-
Cardiff and Vale UHB R&D Office
2nd Floor TB2
University Hospital of Wales
Heath Park
Cardiff CF14 4XW - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Thia, Lena
Recruiting
Countess of Chester Hospital
- Address
-
The Countess Of Chester Health Park
Chester
Cheshire CH2 1UL - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Jayaram, Ravi
Recruiting
HUDDERSFIELD ROYAL INFIRMARY
- Address
-
HUDDERSFIELD ROYAL INFIRMARY, ACRE STREET, HUDDERSFIELD, WEST YORKSHIRE,
HD3 3EA - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Mattara, Abdul
Recruiting
Hull Royal Infirmary
- Address
-
Anlaby Road
Hull HU3 2JZ - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Barraclough, Mary
Recruiting
Kettering General Hospital
- Address
-
Rothwell Road
Kettering
Northamptonshire NN16 8UZ - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Rao, Patti
Recruiting
King's College Hospital (Denmark Hill)
- Address
-
Denmark Hill
London SE5 9RS - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Bossley, Cara
Recruiting
King's Mill Hospital
- Address
-
Mansfield Rd
Sutton-in-Ashfield
Nottinghamshire NG17 4JL - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Yanney, Michael
Recruiting
Leicester Royal Infirmary
- Address
-
Infirmary Square
Leicester
Leicestershire
LE1 5WW - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Gaillard, Erol
Recruiting
New Cross Hospital
- Address
-
WOLVERHAMPTON ROAD HEATH TOWN WOLVERHAMPTON WEST MIDLANDS WV10 0QP
- Recruitment starts
-
- Recruitment ends
-
- Contact
-
Edwards, Sally
Recruiting
Norfolk and Norwich University Hospital (NNUH NHST)
- Address
-
Colney Lane
Colney
Norwich
Norfolk NR4 7UY - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Kavanagh, Caroline
Recruiting
Poole Hospital
- Address
-
Longfleet Road
Poole
Dorset BH15 2JB - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Dewar, Ann
Recruiting
Princess Royal Hospital (Shrewsbury and Telford NHS Trust)
- Address
-
Apley Castle
Grainger Drive
Telford
Shropshire TF1 6TF - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Rees, Martyn
Recruiting
Queen Alexandra Hospital
- Address
-
Queen Alexandra Hospital
Cosham
Portsmouth PO6 3AD - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Buckley, Hannah
Recruiting
Royal Blackburn Teaching Hospital
- Address
-
Royal Blackburn Teaching Hospital
Haslingden Road
Blackburn
Lancashire BB2 3HH - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Robertson, Tanya
Recruiting
Royal Cornwall Hospital (Treliske)
- Address
-
Royal Cornwall Hospital
Treliske
Truro
Cornwall
TR1 3LJ - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Nath, Stuart
Recruiting
Royal Devon and Exeter Hospital (Wonford)
- Address
-
Royal Devon and Exeter Hospital
Barrack Road
Exeter
Devon
EX2 5DW - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Oades, Patrick
Recruiting
Royal Hospital for Children (Glasgow)
- Address
-
Dalnair Street
G3 8SJ - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Thomson, Louise
Recruiting
SALISBURY DISTRICT HOSPITAL
- Address
-
ODSTOCK ROAD SALISBURY WILTSHIRE SP2 8BJ
- Recruitment starts
-
- Recruitment ends
-
- Contact
-
Gray, Sebastian
Recruiting
SHEFFIELD CHILDREN'S HOSPITAL
- Address
-
Western Bank
Sheffield
South Yorkshire S10 2TH - Recruitment starts
-
- Recruitment ends
-
- Contact
-
West, Noreen
Recruiting
Southampton General Hospital
- Address
-
Tremona Road
Southampton
Hampshire SO16 6YD - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Connett, Gary
Recruiting
University Hospitals Bristol NHS Foundation Trust
- Address
-
Marlborough Street, Bristol, Avon
BS1 3NU - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Langton Hewer, Simon
Recruiting
University Hospitals Coventry
- Address
-
University Hospital
Clifford Bridge Road
Coventry CV2 2DX - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Srikantaiah, Rajesh
Recruiting
Worcestershire Royal Hospital
- Address
-
Worcestershire Royal Hospital
Charles Hastings Way
Worcester
Worcestershire WR5 1DD - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Onyon, Clare
Closed
Arrowe Park Hospital
- Address
-
Arrowe Park Road
Upton
Wirral
Merseyside CH49 5PE - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Lacy, David
Closed
Belfast Health and Social Care Trust
- Address
-
Belfast Health and Social Care Trust
Trust Headquarters
A Floor
Belfast City Hospital
Lisburn Road
Belfast BT9 7AB - Contact
-
Reid, Alastair
Closed
Central Manchester University Hospitals NHS Foundation Trust
- Address
-
Trust Headquarters
Cobbett House
Manchester Royal Infirmary
Oxford Road
Manchester
Greater Manchester M13 9WL - Recruitment ends
-
Closed
Gloucestershire Royal Hospital
- Address
-
Great Western Road
Gloucestershire GL1 3NN - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Qayum, Wasim
Closed
Great Ormond Street Hospital
- Address
-
Great Ormond Street
London
WC1N 3JH - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Aurora, Paul
Closed
Heartlands Hospital
- Address
-
Bordesley Green East
Birmingham B9 5SS - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Denniston, Sarah
Closed
John Radcliffe Hospital
- Address
-
HeadingtonHeadley WayOxfordHeadley WayOxfordshire OX3 9DU
Closed
Leeds Children's Hospital
- Address
-
CLARENDON WING
BELMONT GROVE
LEEDS
WEST YORKSHIRE LS2 9NS - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Edwards, Christopher
Closed
Leighton Hospital
- Address
-
Leighton Hospital
Leighton
Crewe
Cheshire CW1 4QJ - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Dowson, Simon
Closed
Lincoln County Hospital
- Address
-
Greetwell Road
Lincoln
Lincolnshire LN2 5QY - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Chingale, Amol
Closed
Musgrove Park Hospital
- Address
-
Musgrove Park Hospital, Taunton, Somerset,
TA1 5DA - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Powell, Alex
Closed
North Devon District Hospital
- Address
-
North Devon District Hospital
Raleigh Park
Barnstaple
Devon EX31 4JB
Closed
Northampton General Hospital (Acute)
- Address
-
Cliftonville
Northampton NN1 5BD - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Collinson, Janet
Closed
Nottingham University NHS Trust - Queen's Medical Centre Campus
- Address
-
Derby Road
Nottingham NG7 2UH - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Smyth, Alan
Closed
Pilgrim Hospital
- Address
-
Sibsey Road
Boston
Lincolnshire PE21 9QS - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Chingale, Amol
Closed
Royal Brompton Hospital
- Address
-
Sydney Street
London SW3 6NP - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Carr, Siobhan
Closed
Royal Lancaster Infirmary
- Address
-
Ashton Rd
Lancaster
LA1 4RP
Closed
Royal Manchester Childrens Hospital - Central Manchester University Hospitals NHS Foundation Trust
- Address
-
Oxford Road
Manchester
M13 9WL
M27 4HA - Recruitment ends
-
- Contact
-
Maitra, Anirban
Closed
Royal Preston Hospital
- Address
-
Sharoe Green Lane
Preston
Lancashire PR2 9HT - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Sugumar, Karnam
Closed
Royal Stoke University Hospital
- Address
-
Royal Stoke University Hospital
Hartshill
Stoke on Trent
Staffordshire ST4 6QG - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Gilchrist, Francis
Closed
Royal United Hospital Bath NHS Trust
- Address
-
Royal United Hospital Bath NHS Trust Combe Park
Bath
BA1 3NG - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Winterson, Rebecca
Closed
ST LUKES HOSPITAL
- Address
-
ST LUKES HOSPITAL, LITTLE HORTON LANE, BRADFORD, WEST YORKSHIRE,
BD5 0NA - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Shenoy, Anil
Closed
Southport and Formby District General Hospital
- Address
-
Town Lane, Kew
Southport
Merseyside
PR8 6PN - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Kandasamy, Sudhakar
Closed
Stepping Hill Hospital - Stockport NHS Foundation Trust
- Address
-
Poplar Grove
Stockport
Cheshire SK2 7JE
Closed
The Royal London Hospital
- Address
-
The Royal London Hospital
Whitechapel
London
E1 1BB - Recruitment ends
-
- Contact
-
Pao, Caroline
Closed
Warrington Hospital
- Address
-
Lovely Lane
Warrington
Cheshire WA5 1QG - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Bedford, Christopher
Closed
Whiston Hospital
- Address
-
Warrington Rd,
Whiston,
Prescot
L35 5DR - Recruitment starts
-
- Recruitment ends
-
- Contact
-
Chilukuri, Lakshmi
Closed
Wythenshawe Hospital Manchester University NHS Foundation Trust
- Address
-
Southmoor Road
Wythenshawe
Manchester
Greater Manchester M23 9LT - Contact
-
Rao, Naveen
Closed
York Hospital
- Address
-
The York Hospital
Wigginton Road
York
North Yorkshire YO31 8HE - Contact
-
Wheeler, Murray