Trials Tracker

The Trials Tracker lists CF clinical trials recruiting in the UK. You can use the filters to find trials based on the trial status, location, participant age and therapeutic approach. To find out more about a specific trial, use the ‘Get in touch’ button on the trial listing. For general advice, see our information on finding clinical trials or contact us. You can also stay informed about UK clinical trial opportunities for people not currently able to benefit from modulators by joining Emily’s Entourage CF Clinical Trial Connect. 

For a broader overview of the CF treatments in development globally, visit the Cystic Fibrosis Foundation’s drug pipeline. 

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Clinical Trials Glossary

1 - 5 of 94 results

A trial investigating the safety and tolerability of RCT2100 in people with CF

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Study details

ReCode Therapeutics Inc. has developed a potential new genetic therapy (RCT2100) for cystic fibrosis. RCT2100 is an inhaled treatment that mimics a natural substance in the body that makes the CFTR protein and may lead to the production of functional CFTR protein and help prevent further damage to the lungs. Part 1 of the study tested RCT2100 in people without CF to determine doses to test in the remainder of the study. We are now recruiting people with CF for Part 2. In Part 2 of the study we will test the safety of different dose levels of RCT2100 in...

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Trials Tracker ID
TT014421
Age range
18 years and older
Length of participation
Approximately 8 months
Trial status
Open to recruitment
Therapeutic approach
Genetic Therapy

A trial investigating a new CREON formulation of pancreatic enzyme replacement therapy medication in people with CF

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Study details

This study will evaluate the acceptability of a new CREON formulation containing pancreas powder gastro-resistant pellets for oral intake. Participants will be asked to attend 3 in person visits over the course of approximately 3 weeks. All participants will take standard CREON capsules with every meal and snack for 7 days. Then, all participants will take the test medication (new CREON formulation) for 8 days with every meal and snack. During both these periods, participants will be asked to complete paper-based diaries. Following the completion of the 8 days on the test medication, participants will also take a paper-based questionnaire...

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Trials Tracker ID
TT014413
Age range
18 years and older
Length of participation
Approximately 3 weeks
Trial status
Recruitment complete
Therapeutic approach
Nutritional-GI

A natural history study of exocrine pancreatic function in infants with CF less than 12 months of age

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Study details

This study is being done to learn more about the pancreas (an organ that helps digest food) and the intestines in infants with CF who are not treated with a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) modulator. A CFTR modulator is a medication that works to correct the protein that is affected in CF. Participants in the study will provide stool samples which will give information about how the infants' digestive system (including the pancreas) is working, and how that may change over time. This information may inform the design and interpretation of future studies of CFTR modulator treatment during...

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Trials Tracker ID
TT014386
Age range
Up to 12 months
Length of participation
Up to 52 weeks
Trial status
Open to recruitment
Therapeutic approach
Observational
Remote participation
Remote participation is possible for this trial

Lenticlair (TM) 1: A study to assess how well a new genetic therapy is tolerated and whether it improves lung function in people with CF

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Study details

This study, called Lenticlair TM 1, aims to find out how well a new genetic therapy is tolerated and whether it improves lung function in people with CF. This is the first time that the genetic therapy will be given to humans. The therapy will be given as an inhaled therapy and is expected to add a healthy copy of the CFTR gene into the cells in the airways. This could help to normalise CFTR function and make the mucus less sticky, improving overall lung function. Find out more about genetic therapies and what’s involved in genetic therapy clinical trials...

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Trials Tracker ID
TT014335
Age range
18 years and older
Length of participation
28 Weeks
Trial status
Open to recruitment
Therapeutic approach
Genetic Therapy

FORMaT: A trial investigating the best treatment for Mycobacterium abscessus infections

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Study details

The aim of this study is to find the safest and most effective treatments for Mycobacterium abscessus (also called M. abscessus) infection in people with CF and non-CF bronchiectasis. There are two groups in this study: an observation group and a treatment group. The observation group will consist of people who either: have only had an M. abscessus infection once or do not currently have signs of M. abscessus infection and are not currently on a treatment for M. abscessus infection. The treatment group will consist of people who have a confirmed M. abscessus infection. Participants in the observation group...

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Trials Tracker ID
TT014236
Age range
Any age
Length of participation
3 years
Trial status
In setup
Therapeutic approach
Anti-Infective

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