CF START

Details

CTAP badge
Therapeutic approach
Anti-Infective
Trial status
Recruitment complete Participating Centres
Trials Tracker ID
TT001671
Last updated
30/09/2020

Full title

The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial (CF START); a randomised registry trial to assess the safety and efficacy of flucloxacillin as a longterm prophylaxis agent for infants with CF.

Study details

CF START is a national UK trial that will determine the safest and most effective antibiotic strategy for infants diagnosed with cystic fibrosis (CF). 480 CF infants will be randomly allocated either flucloxacillin prophylaxis (the current UK standard of care) or antibiotics given in a more targeted manner. The primary outcome will be the age at first growth of Pseudomonas aeruginosa from a respiratory culture (an important safety measure for families). All outcomes will be recorded on a national CF Registry, including a number of secondary outcomes assessing effectiveness and safety. Finally at 40-48 months, a measure of respiratory function will be undertaken in a central laboratory, which will provide a clearer indication of the effectiveness of these two strategies.


Phase
Phase 4
Length of participation
48 months
Recruitment target
480
CF sponsor
Alder Hey Children's NHS Foundation Trust
CF sponsor type
Academic

Who can take part?

Age range
0 to 4 years
Including people

Two CF-causing mutations are identified OR One or no CF- causing mutations identified, sweat chloride test result > 59 mmol/L
Age 90 days or less
Consent for inclusion on the national UK CF Registry
Consent for inclusion in the CF START trial

Excluding people

An inconclusive diagnosis after newborn screening (NBS)
Previous growth of Pseudomonas aeruginosa from respiratory culture

Get in touch

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CF centres running this trial

Closed

Arrowe Park Hospital

NHS Trust
Wirral University Hospital NHS Foundation Trust
Address
Arrowe Park Hospital
Upton, Wirral
CH49 5PE
Local site investigator
David Lacy
Closed

Birmingham Children's Hospital

CTAP centre
NHS Trust
Birmingham Women's and Children's NHS Foundation Trust
Address
Steelhouse Lane
B4 6NH
Local site investigator
Maya Desai
Trial Coordinators
Aoife Neal
Closed

Blackpool Victoria Hospital

CTAP affiliate centre
NHS Trust
Blackpool Teaching Hospitals NHS Foundation Trust
Address
Whinney Heys Road
FY3 8NR
Local site investigator
Alan Rowlands
Closed

Bradford Royal Infirmary

NHS Trust
Bradford Teaching Hospitals NHS Foundation Trust
Address
Duckworth Lane
Bradford
BD9 6RJ
Local site investigator
Jonathan Garside
Closed

Bristol Royal Hospital for Children

CTAP centre
NHS Trust
University Hospitals Bristol NHS Foundation Trust
Address
Upper Maudlin Street
BS2 8BJ
Local site investigator
Simon Langton Hewer
Trial Coordinators
Kate Alderton
Closed

Calderdale Royal Hospital

NHS Trust
Calderdale and Huddersfield NHS Foundation Trust
Address
Salterhebble
Halifax
HX3 0PW
Local site investigator
Abdul Mattara
Closed

Cambridge Addenbrooke's Hospital (Paediatrics)

NHS Trust
Cambridge University Hospitals NHS Foundation Trust
Address
Hills Road
CB2 0QQ
Local site investigator
Donna McShane
Closed

Cardiff - Noah's Ark Children's Hospital for Wales

CTAP centre
NHS Trust
Cardiff and Vale University Health Board
Address
Children and Young Adults Research Unit
Heath Park
CF14 4XW
Local site investigator
Lena Thia
Trial Coordinators
Catherine Joyce
Closed

Countess of Chester Hospital

NHS Trust
The Countess of Chester Hospital NHS Foundation Trust
Address
The Countess of Chester Health Park
Chester
CH2 1UL
Local site investigator
Ravi Jayaram
Closed

Glasgow - Royal Hospital for Children

CTAP centre
NHS Trust
NHS Greater Glasgow & Clyde
Address
Yorkhill
G3 8SJ
Local site investigator
Louise Thomson
Trial Coordinators
Annie Husband
Closed

Gloucestershire Royal Hospital

NHS Trust
Gloucestershire Hospitals NHS Foundation Trust
Address
Great Western Road
GL1 3NN
Local site investigator
Wasim Qayum
Closed

Great Ormond Street Hospital for Children (London)

CTAP centre
NHS Trust
Great Ormond Street Hospital for Children NHS Foundation Trust
Address
Great Ormond Street
WC1N 3JH
Local site investigator
Paul Aurora
Trial Coordinators
Lucy Holt
Closed

Huddersfield Royal Infirmary

NHS Trust
Calderdale and Huddersfield NHS Foundation Trust
Address
Acre Street
Huddersfield
HD3 3EA
Local site investigator
Abdul Mattara
Closed

Hull Royal Infirmary

NHS Trust
Hull University Teaching Hospitals NHS Trust
Address
Anlaby Road
HU3 2JZ
Local site investigator
Haji Muhammad Sheeraz Khan
Closed

Kettering General Hospital

NHS Trust
Kettering General Hospital NHS Foundation Trust
Address
Rothwell Road
Kettering
NN16 8UZ
Local site investigator
Patti Rao
Closed

King's College Hospital (London)

CTAP centre
NHS Trust
King's College Hospital NHS Foundation Trust
Address
King's College Hospital
Denmark Hill
SE5 9RS
Local site investigator
Cara Bossley
Trial Coordinators
Mélanie Le Sayec
Closed

King's Mill Hospital - Sutton-In-Ashfield

NHS Trust
Sherwood Forest Hospitals NHS Foundation Trust
Address
Mansfield Road
Sutton-in-Ashfield
NG17 4JL
Local site investigator
Michael Yanney
Closed

Leeds Children's Hospital

CTAP centre
NHS Trust
The Leeds Teaching Hospitals NHS Trust
Address
Clarendon Wing
Belmont Grove
LS2 9NS
Local site investigator
Christopher Edwards
Trial Coordinators
Yasmin Khanagha
Closed

Leicester Royal Infirmary (Paediatrics)

CTAP affiliate centre
NHS Trust
University Hospitals of Leicester NHS Trust
Address
Infirmary Square
LE1 5WW
Local site investigator
Erol Gaillard
Closed

Leighton Hospital - Cheshire

NHS Trust
Mid Cheshire Hospitals NHS Foundation Trust
Address
Leighton
Crewe
CW1 4QJ
Local site investigator
Simon Dowson
Closed

Lincoln County Hospital

NHS Trust
United Lincolnshire Hospitals NHS Trust
Address
Greetwell Road
Lincoln
LN5 5QY
Local site investigator
Amol Chingale
Closed

Liverpool - Alder Hey Children's Hospital

CTAP centre
NHS Trust
Alder Hey Children's NHS Foundation Trust
Address
Eaton Road
West Derby
L12 2AP
Trial Coordinators
Victoria King
Closed

Manchester (Adults) - Wythenshawe Hospital

CTAP centre
NHS Trust
Manchester University NHS Foundation Trust
Address
Wythenshawe Hospital
South Moor Road
M23 9LT
Local site investigator
Naveen Rao
Trial Coordinators
Sarah Sampson
Closed

Musgrove Park Hospital - Somerset

NHS Trust
Somerset NHS Foundation Trust
Address
Taunton
TA1 5DA
Local site investigator
Alex Powell
Closed

New Cross Hospital - Wolverhampton

NHS Trust
The Royal Wolverhampton NHS Trust
Address
Wolverhampton Road
Health Town
WV10 0QP
Local site investigator
Sally Edwards
Closed

Norfolk & Norwich University Hospital (Paediatrics)

CTAP affiliate centre
NHS Trust
Norfolk and Norwich University Hospitals NHS Foundation Trust
Address
Colney Lane
NR4 7UY
Local site investigator
Caroline Kavanagh
Closed

North Devon District Hospital

NHS Trust
Royal Devon University Healthcare NHS Foundation Trust
Address
Raleigh Park
Barnstaple
EX31 4JB
Closed

Northampton General Hospital

NHS Trust
Northampton General Hospital NHS Trust
Address
Cliftonville
NN1 5BD
Local site investigator
Janet Collinson
Closed

Nottingham Children's Hospital (Paediatrics)

CTAP centre
NHS Trust
Nottingham University Hospitals NHS Foundation Trust
Address
Queen's Medical Centre
Derby Road
NG7 2UH
Local site investigator
Alan Smyth
Trial Coordinators
Gillian Black
Closed

Oxford - John Radcliffe Hospital (Paediatrics)

CTAP affiliate centre
NHS Trust
Oxford University Hospitals NHS Foundation Trust
Address
Headley Way
OX3 9DU
Closed

Pilgrim Hospital - Lincolnshire

NHS Trust
United Lincolnshire Hospitals NHS Trust
Address
Sibsey Road
Boston
PE21 9QS
Local site investigator
Amol Chingale
Closed

Poole Hospital

NHS Trust
University Hospitals Dorset NHS Foundation Trust
Address
Longfleet Road
Poole
BH15 2JB
Local site investigator
Ann Dewar
Closed

Princess Royal Hospital

NHS Trust
Shrewsbury and Telford NHS Trust
Address
Apley Castle
Grainger Drive, Telford
TF1 6TF
Local site investigator
Martyn Rees
Closed

Queen Alexandra Hospital - Portsmouth

NHS Trust
Portsmouth Hospitals University NHS Trust
Address
Cosham
PO6 3AD
Local site investigator
Hannah Buckley
Closed

Royal Belfast Hospital for Sick Children

CTAP centre
NHS Trust
Belfast Health & Social Care Trust
Address
180 Falls Road
BT12 6BE
Local site investigator
Alastair Reid
Trial Coordinators
Catherine McNeill
Closed

Royal Blackburn Hospital

NHS Trust
East Lancashire Hospitals NHS Trust
Address
Haslingden Road
Blackburn
BB2 3HH
Local site investigator
Tanya Robertson
Closed

Royal Brompton Hospital (London)

CTAP centre
NHS Trust
Guy's and St Thomas' NHS Foundation Trust
Address
Royal Brompton Hospital
Sydney Street
SW3 6NP
Local site investigator
Siobhan Carr
Trial Coordinators
Sophie Pinnell
Closed

Royal Cornwall Hospital

NHS Trust
Royal Cornwall Hospitals NHS Trust
Address
Treliske
Truro
TR1 3LJ
Local site investigator
Stuart Nath
Closed

Royal Devon & Exeter Hospital

CTAP centre
NHS Trust
The Royal Devon & Exeter NHS Foundation Trust
Address
Barrack Road
EX2 5DW
Local site investigator
Beth Enderby
Trial Coordinators
Sophie Whiteley
Closed

Royal Lancaster Infirmary

NHS Trust
University Hospitals of Morecambe Bay NHS Foundation Trust
Address
Ashton Road
LA1 4RP
Closed

Royal Manchester Children's Hospital (Paediatrics)

CTAP centre
NHS Trust
Manchester University NHS Foundation Trust
Address
Oxford Road
M13 9WL
Local site investigator
Anirban Maitra
Trial Coordinators
Sarah Sampson
Closed

Royal Preston Hospital

NHS Trust
Lancashire Teaching Hospitals NHS Foundation Trust
Address
Sharoe Green Lane
Preston
PR2 9HT
Local site investigator
Karnam Sugumar
Closed

Royal Stoke University Hospital (Paediatrics)

CTAP affiliate centre
NHS Trust
University Hospitals of North Midlands NHS Trust
Address
Newcastle Road
Stoke-on-Trent
ST4 6QG
Local site investigator
Francis Gilchrist
Closed

Royal Sussex County Hospital

NHS Trust
University Hospitals Sussex NHS Foundation Trust
Address
Eastern Road
BN2 5BE
Local site investigator
Paul Seddon
Closed

Royal United Hospital - Bath

NHS Trust
Royal United Hospitals Bath NHS Foundation Trust
Address
Combe Park
BA1 3NG
Local site investigator
Rebecca Winterson
Closed

Salisbury District Hospital

NHS Trust
Salisbury NHS Foundation Trust
Address
Odstock Road
Salisbury
SP2 8BJ
Local site investigator
Sebastian Grey
Closed

Sheffield Children's Hospital

CTAP affiliate centre
NHS Trust
Sheffield Children's NHS Foundation Trust
Address
Western Bank
S10 2TH
Local site investigator
Noreen West
Closed

Southampton General Hospital

CTAP centre
NHS Trust
University Hospital Southampton NHS Foundation Trust
Address
Tremona Road
SO16 6YD
Local site investigator
Gary Connett
Trial Coordinators
Matthew Harvey
Closed

Southport and Formby District General Hospital

NHS Trust
Southport and Omskirk Hospital NHS Trust
Address
Town Lane
Southport
PR8 6PN
Local site investigator
Sudhakar Kandasamy
Closed

St Luke's Hospital - Bradford

NHS Trust
Bradford Teaching Hospitals NHS Foundation Trust
Address
Little Horton Lane
Bradford
BD5 0NA
Local site investigator
Jonathan Garside
Closed

Stepping Hill Hospital - Stockport

NHS Trust
Stockport NHS Foundation Trust
Address
Poplar Grove
Stockport
SK2 7JE
Closed

The Royal London Hospital

CTAP centre
NHS Trust
Barts Health NHS Trust
Address
2nd Floor Fieldon House
Whitechapel
E1 1BB
Local site investigator
Caroline Pao
Trial Coordinators
Sandra Pereira
Closed

University Hospital Coventry & Warwickshire

NHS Trust
University Hospitals Coventry & Warwickshire NHS Trust
Address
Clifford Bridge Road
CV2 2DX
Local site investigator
Rajesh Srikantaiah
Closed

Warrington Hospital - Cheshire

NHS Trust
Warrington and Halton Teaching Hospitals NHS Foundation Trust
Address
Lovely Lane
Warrington
WA5 1QG
Local site investigator
Elinor Thomason
Closed

Whiston Hospital - Prescot

NHS Trust
St Helens and Knowsley Teaching Hospitals NHS Trust
Address
Warrington Road
Whiston
L35 5DR
Local site investigator
Lakshmi Chilukuri
Closed

Wishaw General Hospital

NHS Trust
NHS Lanarkshire
Address
50 Netherton Street
ML2 0DP
Local site investigator
Donna Corrigan
Closed

Worcestershire Royal Hospital

NHS Trust
Worcestershire Acute Hospitals NHS Trust
Address
Charles Hastings Way
Worcester
WR5 1DD
Local site investigator
Clare Onyon
Closed

York Hospital

NHS Trust
York and Scarborough Teaching Hospitals NHS Foundation Trust
Address
Wigginton Road
York
YO31 8HE
Local site investigator
Murray Wheeler