Research in focus reports

Our Research in focus reports aim to give an overview of an aspect of cystic fibrosis where our funding is making a difference.

Front cover image of Research in focus on Pseudomonas aeruginosa infections in CF

Research in focus: Pseudomonas aeruginosa infections

Cystic fibrosis causes thick, sticky mucus to build up in the airways. This prevents the body from being able to effectively remove bacteria, and can cause serious, hard to treat infections. Four out of 10 adults with CF live with infections caused by Pseudomonas aeruginosa (P. aeruginosa). In September 2020 we published our Research in focus report on P. aeruginosa infections, sharing the progress Trust-funded researchers are making in understanding how this bug adapts itself within the CF lungs. Understanding how this bug adapts may give us novel approaches to treat these infections in the future.

The Research in focus: Pseudomonas aeruginosa infections report is now available to download.

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front cover of the Research in focus report showing scientist in lab

Research in focus: gut symptoms of cystic fibrosis

Our Research in focus report on gut symptoms of cystic fibrosis was published in June 2021. Many people will experience CF-related symptoms gut pain, visible bloating and flatulence and we know that relief of these symptoms is a priority for the CF community. Currently little is known about how the physiological and biochemical changes within the intestines lead to these symptoms. Our report highlights two Trust-funded research studies that if successful could lead to clinical trials of new medicines to treat these painful and embarrassing symptoms of cystic fibrosis.

The Research in focus: gut symptoms of cystic fibrosis report is now available to download.

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Front cover of a report called Research in focus on genetic therapies

Research in focus: Genetic therapies in cystic fibrosis

In December 2020 we published a research in focus report on genetic therapies in cystic fibrosis. Genetic therapies have the potential to treat the underlying cause of CF for everyone with the condition. The report explains why genetic therapies are important in CF, how they work and the research the Trust has funded exploring a type of genetic therapy called gene editing.

The Research in focus: Genetic therapies in cystic fibrosis report is now available to download.

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Additional resources

More detail about some of the topics raised in our Research in focus report on genetic therapies in CF can be found on the following pages:

Cover of the Research in focus on antimicrobial resistance report

Research in focus: Antimicrobial resistance in cystic fibrosis

In October 2020 we published a research in focus report on antimicrobial resistance (AMR) in cystic fibrosis. While AMR is a concern for us all, people living with CF are particularly vulnerable to it. The report highlights how CF researchers are leading the way in tackling AMR in CF, and how the ground-breaking approaches described in this report will be beneficial for people with CF in the future. Innovations made in tackling AMR in CF will also be applicable to solving AMR for all those with drug-resistant infections.

The Research in focus: Antimicrobial resistance in cystic fibrosis report is now available to download

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Cover of the Research in focus on antimicrobial resistance report

Research in focus: Cystic fibrosis-related diabetes

In June 2020 we published a Research in focus report on CF related diabetes. The report explains the impact CF-related diabetes has on the lives of people with cystic fibrosis (CF), what we’ve learnt from our funding so far, and how a new Strategic Research Centre grant could pave the way for insulin-injection free treatments in the future.

The Research in focus: Cystic fibrosis related diabetes report is now available to download.

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Additional resources on CF-related diabetes

More detail about some of the topics raised in our Research in Focus report on CF-related diabetes can be found on the following pages:

Research we fund

We fund research to tackle some of the most pressing issues in CF today. Find out how your donations are making a difference.

What is CF?

Cystic fibrosis, or CF, affects the lungs, digestive system and other organs, and there are over 10,600 people living with it in the UK.

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