The CF STORM Trial

Details

CTAP badge
Therapeutic approach
Other
Trial status
Open to recruitment Participating Centres
Trials Tracker ID
TT005796
Last updated
12/05/2022

Full title

CF STORM; A trial to assess change in respiratory function for people with cystic fibrosis on triple combination therapy (Kaftrio™) after rationalisation of nebulised mucoactive therapies

Study details

For people with cystic fibrosis (pwCF), how to reduce treatment burden has been identified as the top priority research question. Daily nebulised treatments were identified by pwCF as burdensome.

The CF STORM trial will recruit pwCF age 6 years and above that have been established on Kaftrio™ therapy. They will have an equal chance of being allocated to either stop or continue their daily nebulised muco-active therapies (dornase alfa, hypertonic saline or both).

The trial is designed to provide confidence that stopping these nebulisers does not result in a significant decline in lung function over 12 months.

The trial will not involve extra visits outside of normal clinical care.

https://www.cfstorm.org.uk/


Phase
Phase 4
Recruitment target
764
CF sponsor
Alder Hey - Liverpool
CF sponsor type
Academic

Who can take part?

Age range
6+
Including people

1) Established on Kaftrio™ therapy for more than 3 months
2) FEV1 > 40 percent predicted
3) Established on daily muco-active therapies (dornase alfa (Pulmozyme™), hypertonic saline or both) for more than 3 months
4) 6 years and older

Get in touch

Your donation will make a difference:

Select amount
Select amount

CF centres running this trial

Recruiting

Belfast City Hospital (Adults)

CTAP centre
NHS Trust
Belfast Health & Social Care Trust
Address
Lisburn Road
BT9 7AB
Local site investigator
Damian Downey
Trial Coordinators
Catherine McNeill
Recruiting

Birmingham Children's Hospital

CTAP centre
NHS Trust
Birmingham Women's and Children's NHS Foundation Trust
Address
Steelhouse Lane
B4 6NH
Local site investigator
Maya Desai
Trial Coordinators
Aoife Neal
Recruiting

Birmingham Heartlands Hospital (Adults)

CTAP centre
NHS Trust
University Hospitals Birmingham NHS Foundation Trust
Address
Bordesley Green
B9 5SS
Local site investigator
Joanna Whitehouse
Trial Coordinators
Aoife Neal
Recruiting

Blackpool Victoria Hospital

CTAP affiliate centre
NHS Trust
Blackpool Teaching Hospitals NHS Foundation Trust
Address
Whinney Heys Road
FY3 8NR
Local site investigator
Tarek Saba
Recruiting

Bristol Royal Hospital for Children

CTAP centre
NHS Trust
University Hospitals Bristol NHS Foundation Trust
Address
Upper Maudlin Street
BS2 8BJ
Local site investigator
Simon Langton Hewer
Trial Coordinators
Kate Alderton
Recruiting

Bristol Royal Infirmary (Adults)

CTAP centre
NHS Trust
University Hospitals Bristol NHS Foundation Trust
Address
Marlborough Street
BS2 8HW
Local site investigator
Nicholas Bell
Trial Coordinators
Sally Coplowe
Recruiting

Cambridge Royal Papworth Hospital (Adults)

CTAP centre
NHS Trust
Royal Papworth Hospital NHS Foundation Trust
Address
Papworth Road
CB2 0AY
Local site investigator
Charles Haworth
Trial Coordinators
Deepa George
Victoria Christenssen
Recruiting

Cardiff - University Hospital Llandough (Adults)

CTAP centre
NHS Trust
Cardiff and Vale University Health Board
Address
Penland Road
Llandough
CF64 2XX
Local site investigator
Jamie Duckers
Trial Coordinators
Catherine Joyce
Recruiting

Edinburgh - Western General Hospital (Adults)

CTAP centre
NHS Trust
NHS Lothian
Address
Crewe Road South
EH4 2XU
Trial Coordinators
Ellyse Kilarski
Recruiting

Glasgow - Royal Hospital for Children

CTAP centre
NHS Trust
NHS Greater Glasgow & Clyde
Address
Yorkhill
G3 8SJ
Trial Coordinators
Annie Husband
Recruiting

Great Ormond Street Hospital for Children (London)

CTAP centre
NHS Trust
Great Ormond Street Hospital for Children NHS Foundation Trust
Address
Great Ormond Street
WC1N 3JH
Local site investigator
Gwyneth Davies
Trial Coordinators
Lucy Holt
Recruiting

Hull Royal Infirmary

NHS Trust
Hull University Teaching Hospitals NHS Trust
Address
Anlaby Road
HU3 2JZ
Local site investigator
Mary Barraclough
Recruiting

King's College Hospital (London)

CTAP centre
NHS Trust
King's College Hospital NHS Foundation Trust
Address
King's College Hospital
Denmark Hill
SE5 9RS
Local site investigator
Cara Bossley
Trial Coordinators
Mélanie Le Sayec
Recruiting

Leeds Children's Hospital

CTAP centre
NHS Trust
The Leeds Teaching Hospitals NHS Trust
Address
Clarendon Wing
Belmont Grove
LS2 9NS
Local site investigator
Timothy Lee
Trial Coordinators
Yasmin Khanagha
Recruiting

Leicester - Glenfield Hospital (Adults)

CTAP affiliate centre
NHS Trust
University Hospitals of Leicester NHS Trust
Address
Groby Road
LE3 9QP
Recruiting

Leicester Royal Infirmary (Paediatrics)

CTAP affiliate centre
NHS Trust
University Hospitals of Leicester NHS Trust
Address
Infirmary Square
LE1 5WW
Local site investigator
Andrew Clayton
Recruiting

Liverpool - Alder Hey Children's Hospital

CTAP centre
NHS Trust
Alder Hey Children's NHS Foundation Trust
Address
Eaton Road
West Derby
L12 2AP
Local site investigator
Rebecca Thursfield
Trial Coordinators
Victoria King
Recruiting

Liverpool Heart and Chest Hospital

NHS Trust
Liverpool Heart and Chest Hospital NHS Foundation Trust
Address
Thomas Drive
Liverpool
L14 3PE
Local site investigator
Dilip Nazareth
Recruiting

Manchester (Adults) - Wythenshawe Hospital

CTAP centre
NHS Trust
Manchester University NHS Foundation Trust
Address
Wythenshawe Hospital
South Moor Road
M23 9LT
Trial Coordinators
Sarah Sampson
Recruiting

Newcastle - Royal Victoria Infirmary (Adults)

CTAP affiliate centre
NHS Trust
The Newcastle-upon-Tyne Hospitals NHS Foundation Trust
Address
Queen Victoria Road
NE1 4LP
Recruiting

Nottingham Children's Hospital (Paediatrics)

CTAP centre
NHS Trust
Nottingham University Hospitals NHS Foundation Trust
Address
Queen's Medical Centre
Derby Road
NG7 2UH
Trial Coordinators
Gillian Black
Recruiting

Nottingham City Hospital (Adults)

CTAP centre
NHS Trust
Nottingham University Hospitals NHS Foundation Trust
Address
City Hospital, Wolfson Cystic Fibrosis Centre
Hucknall Road
NG5 1PB
Trial Coordinators
Fozia Naushahi
Recruiting

Oxford - John Radcliffe Hospital

CTAP affiliate centre
NHS Trust
Oxford University Hospitals NHS Foundation Trust
Address
Headley Way
OX3 9DU
Recruiting

Royal Alexandra Children's Hospital - Brighton

NHS Trust
Brighton and Sussex University Hospitals NHS Trust
Address
Eastern Road
BN2 5BE
Local site investigator
Tom Ruffles
Recruiting

Royal Brompton Hospital (London)

CTAP centre
NHS Trust
Guy's and St Thomas' NHS Foundation Trust
Address
Royal Brompton Hospital
Sydney Street
SW3 6NP
Local site investigator
Rishi Pabary
Trial Coordinators
Sophie Pinnell
Recruiting

Royal Devon & Exeter Hospital

CTAP centre
NHS Trust
The Royal Devon & Exeter NHS Foundation Trust
Address
Barrack Road
EX2 5DW
Local site investigator
Beth Enderby
Trial Coordinators
Sophie Whiteley
Recruiting

Royal Manchester Children's Hospital (Paediatrics)

CTAP centre
NHS Trust
Manchester University NHS Foundation Trust
Address
Oxford Road
M13 9WL
Trial Coordinators
Sarah Sampson
Recruiting

Southampton General Hospital

CTAP centre
NHS Trust
University Hospital Southampton NHS Foundation Trust
Address
Tremona Road
SO16 6YD
Local site investigator
Mary Carroll
Trial Coordinators
Matthew Harvey
Recruiting

St Bartholomew's Hospital (London) - Adults

CTAP centre
NHS Trust
Barts Health NHS Trust
Address
West Smithfield
EC1A 7BE
Local site investigator
Danie Watson
Trial Coordinators
Sandra Pereira
Recruiting

St James's University Hospital - Leeds (Adults)

CTAP centre
NHS Trust
The Leeds Teaching Hospitals NHS Trust
Address
St James's University Hospital
Beckett Street
LS9 7TF
Local site investigator
Daniel Peckham
Trial Coordinators
Helen Chadwick
Recruiting

The Royal London Hospital

CTAP centre
NHS Trust
Barts Health NHS Trust
Address
2nd Floor Fieldon House
Whitechapel
E1 1BB
Local site investigator
Caroline Pao
Trial Coordinators
Sandra Pereira
Recruiting

University Hospital Lewisham

NHS Trust
Lewisham and Greenwich NHS Trust
Address
Lewisham High Street
SE13 6LH
Local site investigator
Lucy Baker