Bronchiectasis research: treating a common CF lung complication

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Bronchiectasis is a chronic lung condition that is a common complication of CF – although it isn’t always talked about using this term. Here we explain more about what bronchiectasis is and the AIRTIVITY™ study looking at a potential new treatment. 

How is bronchiectasis related to CF? 

Bronchiectasis is a chronic lung condition where the airways become widened and damaged. Many people with CF have bronchiectasis, although it isn’t always talked about in this way. In CF, thick mucus can obstruct the airways and cause them to become widened and inflamed. If this damage becomes permanent this is called bronchiectasis. 

Although only about 2% of all people with bronchiectasis have CF, a large number of adults with CF develop bronchiectasis. Because of this, CF can be seen as a specific cause of bronchiectasis. 

Researching a potential new treatment 

A study called the AIRTIVITY™ study is aiming to find out whether a new anti-inflammatory medicine can help people with bronchiectasis, including people with and without CF. It is currently looking for people with CF to join the study.

The study is looking at whether the medicine helps reduce symptoms in people with bronchiectasis, regardless of the underlying cause. It is a phase 3 study, meaning that previous phases of the trial looked at how safe and well tolerated the medicine is, and this phase is now looking at whether it can reduce the number of flare-ups (also called exacerbations), slow down worsening of lung function, and improve quality of life. 

Join the study today

The AIRTIVITY™ study is currently looking for people with CF to take part. You may be able to take part if you have bronchiectasis and have had flare-ups needing antibiotic treatment in the past 12 months. 

Please talk with your CF team if you are unsure if you have bronchiectasis as part of your CF.

Find out more about the AIRTIVITY™ study and how to join


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