A CFit Study: To what extent does inflammation, oxidative stress, nitric oxide bioavailability and microvascular endothelial dysfunction influence the aerobic exercise function of individuals with cystic fibrosis, with and without established diabetes (The CFit Study)
Adults with CF regularly receive anti-infective therapy that can result in impaired hearing. Recent studies have identified that up to 50% of adults with CF have hearing loss with resulting significant impact on quality of life. At present, however, there is no national recommendation to screen for hearing loss within adult CF. Formal hearing tests are costly, require specialist staff and equipment and require further outpatient visits resulting in significant impact on health, social and financial resource. A novel interactive Apple-iPad app-based audiometer is now available and CE marked (Shoebox MD, Clearwater Medical) that can be used by non-audiologists to...
Trials Tracker ID
TT001796
Age range
16+
Length of participation
Two visits which include three hearing tests, a blood test and questionnaires.
Through interviewing both the patient with CF and their families, this study hopes to establish a clearer picture of the effect the condition can have on the individual themselves and on their immediate family, in various aspects of their lives. From this, we hope to understand the key challenges facing these populations to help tailor the development of services.
Cystic Fibrosis (CF) affects more than 10000 people in the UK. The lungs of people with CF (PWCF) are prone to infections and require daily medication to stay healthy. Average adherence to medication has been shown to be only 36%. Poor adherence is associated with poor clinical outcomes including distressing unscheduled hospitalisations. Previous research has been undertaken to design a website (CFHealthhub) which records personal adherence data using chipped nebulisers and understand whether this can build successful treatment habits. In the current project we will develop CFHealthHub as a data observatory which will record adherence data and other indicators of...
The paediatric research team in the Royal Brompton Hospital, London, are investigating the impact of CFTR modulators on children exposed to the medication during pregnancy and breast feeding. Although our current understanding is that it appears to be safe, guidelines are not yet available on how to follow up this group of babies to ensure they do remain unaffected.
James is a second year, Trust-funded PhD student based at Bristol University. In the latest of our ‘Inside the lab’ series, he tells us what his research is about and what a typical day looks like for him.
