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‘Noisy whispers’ – how rare, brief openings of the CF protein could improve the design of new medicines

Cystic fibrosis is caused by the absence of, or faults in, the CF transmembrane conductance regulator (CFTR) protein (shortened here to the ‘CF protein’). James Charlick, based at the University of Bristol, will use his Early Career Researcher Development Award to explore the implications of new insights into how the CF protein works at a microscopic level. Understanding tiny details about faults in this protein can help researchers design more effective medicines for CF and make them available to a wider group of people.
a lady and a man wearing yellow cystic fibrosis tops, holding a yellow foam finger and yellow cystic fibrosis banner

Cardiff Half Marathon

Event Date: 03/10/2027
Experience a flat, fast and scenic tour of the Welsh capital at one of Europe's best supported running events.

Improving the diagnosis and treatment of CF lung infections and maintaining lung health

People with CF are at a high risk of developing lung infections, because of the thick sticky mucus in their lungs and lung damage from previous infections. CF lung infections can cause breathlessness and difficulty breathing. They can cause major disruptions to day-to-day life and may lead to permanent lung damage. We need detect and diagnose these infections quickly and we need more effective medicines to treat them.

Employment stories

As part of our Work Forwards programme of employment support, we're sharing career stories and insights from people from the cystic fibrosis (CF) community.

Meet the team

Meet the Executive Team, Board of Trustees and President at mCystic Fibrosis Trust.